期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 92, 期 1, 页码 135-140出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2008.11.004
关键词
Nitric oxide; Nitric oxide synthase; Minocycline; Nicotine dependence; Intravenous nicotine
资金
- Veterans Administration Mental Illness Research, Education and Clinical Center (MIRECC)
- NIH [P50-AA-015632, K02-DA-021304, K01-DA-019446, K05-AA-014715]
In recent preclinical studies, the role of nitric oxide (NO) in nicotine dependence has become increasingly evident. Inhibition of NO synthesis blocks acquisition of conditioned place preference, and attenuates the nicotine abstinence syndrome in rodents. These findings have not been followed up in human studies. In order to obtain preliminary data on NO inhibition in human smokers, we conducted a randomized, double-blind, crossover study (N = 12) of minocycline, a tetracycline derivative antibiotic, that inhibits the neuronal nitric oxide (NO) synthase enzyme with resultant inhibition of NO production. Medication effects were assessed through a smoking choice procedure as well as subjective and physiological responses to nicotine administered via the intravenous route (IV). Minocycline treatment did not affect smoking self-administration in Our choice procedure and did not affect most of the subjective responses to IV nicotine or sample smoking. Following IV nicotine administration. there was a greater reduction in craving for cigarettes under minocycline, compared to placebo. Similarly. smokers had greater reduction in their craving for cigarettes following sample smoking under minocycline treatment. These findings provide limited support for the potential use of minocycline as a treatment of nicotine dependence. (C) 2008 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据