期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 92, 期 2, 页码 272-276出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2008.12.010
关键词
Acute stress; Chronic stress; Adaptation; Nitric oxide; Oxidative stress; ROS-RNS interactions
资金
- Department of Science and Technology (DST)
The present study evaluated the effects of acute and chronic restraint stress (RS 1 h or 6 h). and their modulation by nitrergic agents on neurobehavioral and oxidative stress markers in rats. Acute RS (1 h or 6 h) reduced open arm entries (OAE) and open arm time (OAT) in the elevated plus maze test - which were attenuated by the NO precursor. L-arginine but not influenced appreciably by the NO synthase inhibitor, L-NAME. These behavioral changes were associated with differential changes in brain NO metabolites (NOx) but consistently reduced GSH and raised MDA levels in comparison to the control group. Following RS 1 h x 10 the neurobehavioral suppression and changes in brain oxidative stress markers were less pronounced as compared to the acute RS (1 h) group indicating adaptation. L-arginine pretreatment facilitated this adaptation to chronic RS (1 h). Interestingly RS 6 h x 10, induced severe behavioral suppression and aggravation of MDA and NOx levels and L-NAME pretreatment tended to protect against these chronic RS induced aggravations. These results suggest that acute and chronic RS induces duration/intensity dependent neurobehavioral and oxidative injury which are under the differential regulatory control of NO. (C) 2008 Elsevier Inc. All rights reserved.
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