期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 90, 期 3, 页码 387-393出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2008.03.013
关键词
impulsivity; D-4 receptors; mice; delay discounting; Go/No-go; inhibition; novelty seeking; locomotion
资金
- NIAAA NIH HHS [P60 AA010760, T32 AA007468-21, T32 AA007468, 5 T32-AA07468] Funding Source: Medline
- NIDA NIH HHS [R01 DA016727-04, R01 DA016727] Funding Source: Medline
- NIMH NIH HHS [MH070219, F31 MH070219-03, R01 MH067497-05, R01 MH067497, MH67497, F31 MH070219] Funding Source: Medline
Alleles of the human dopamine D-4 receptor (D4R.) gene (DRD4.7) have repeatedly been found to correlate with novelty seeking, substance abuse, pathological gambling, and attention-deficit hyperactivity disorder (ADHD). If these various psycho pathologies are a result of attenuated D4R-mediated signaling, mice lacking D(4)Rs (D4KO) should be more impulsive than wild-type (WT) mice and exhibit more novelty seeking. However, in our study, D4KO and WT mice showed similar levels of impulsivity as measured by delay discounting performance and response inhibition on a Go/No-go test, suggesting that D4R-mediated signaling may not affect impulsivity. D4KO mice were more active than WT mice in the first 5 min of a novel open field test, suggesting greater novelty seeking. For both genotypes, more impulsive mice habituated less in the novel open field. These data suggest that the absence of D(4)Rs is not sufficient to cause psychopathologies associated with heightened impulsivity and novelty seeking. (C) 2008 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据