期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 90, 期 3, 页码 497-500出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2008.04.012
关键词
cocaine; alcohol; vulnerability; maternal care; licking and grooming; drug self-administration
资金
- NCRR NIH HHS [RR00165, P51 RR000165-477543, P51 RR000165] Funding Source: Medline
- NIDA NIH HHS [DA00418, K05 DA000418, K05 DA000418-09] Funding Source: Medline
Because licking and grooming behavior of dams with pups can influence some behaviors of pups when they are adults, we tested if licking and grooming scores in a maternal separation protocol correlated with cocaine or ethanol self-administration in the pups as adults. The protocol produced litters that were separated from dams for 0 (MSO), 15 (MS15) or 180 (MS180) min, and a nonhandled (NH) group as well. Self-administration of both drugs as shown in earlier studies was lowest in the MS15 group, highest in the NH group and intermediate in the other groups. Licking and grooming scores correlated negatively with drug intake and suggests that maternal care of pups can influence drug use in pups when they are adults. (C) 2008 Elsevier Inc. All rights reserved.
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