期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 90, 期 4, 页码 735-741出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2008.06.001
关键词
amphetamine; alpha-methyl-p-tyrosine; rewarding brain stimulation; rate-frequency curve; dopamine; aging; aged; reinforcement
资金
- Natural Science and Engineering Research Council of Canada
- Canadian Institutes for Health Research
In old age there is evidence of waning motivation, and possibly lowering of mood. Physiologically there is a decline in the levels of brain neurotransmitters such as acetylcholine and dopamine, and loss of myelin. These changes might be expected to impair the functioning of brain circuitry for reinforcement, and to lead to impaired motivation. To evaluate the function of brain reinforcement mechanisms during aging we examined brain stimulation reward and its modulation by dopaminergic drugs in BN F344F1 rats aged from young adult (5 months) to old (37 months). Brain stimulation directly activates the neural circuitry for reinforcement, and the response rate-frequency tradeoff can be used to characterize the functioning of the system. Both young and old subjects readily learned to]ever press for 0.6 s trains of 0.15 ms brain stimulation pulses, and there was no difference in the number of pulses per train required to maintain responding at 50% of the maximum rate (M50). Amphetamine (0.5 mg/kg) significantly reduced the M50, and the dopamine synthesis inhibitor alpha-methyl-p-tyrosine (100 mg/kg) increased the 1050, but these effects were not influenced by the age of the subjects. The results suggest that in healthy animals dopaminergic modulation of reinforcement is functionally intact in old age. (C) 2008 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据