期刊
PHARMACOLOGY & THERAPEUTICS
卷 142, 期 2, 页码 141-153出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2013.12.002
关键词
Hypoxic preconditioning; Ischemic preconditioning; Stem cell; Cell therapy; Tissue engineering; Paracrine
资金
- National Heart Foundation
- National Health and Medical Research Council of Australia
- JR and JO Wicking Trust
- Victorian State Government's Department of Innovation, Industry and Regional Development's Operational Infrastructure Support Program
Cell- and tissue-based therapies are innovative strategies to repair and regenerate injured hearts. Despite major advances achieved in optimizing these strategies in terms of cell source and delivery method, the clinical outcome of cell-based therapy remains unsatisfactory. The non-genetic approach of ischemic/hypoxic preconditioning to enhance cell-and tissue-based therapies has received much attention in recent years due to its non-invasive drug-free application. Here we discuss the current development of hypoxic/ischemic preconditioning to enhance stem cell-based cardiac repair and regeneration. (C) 2013 Elsevier Inc All rights reserved.
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