期刊
PHARMACOLOGY & THERAPEUTICS
卷 120, 期 2, 页码 186-196出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2008.08.007
关键词
Influenza; CD8+T cells; Cytotoxicity; Memory; TCR repertoire; Vaccine; Ageing
Antigen-specific CD8+ T cells play an important role in virus clearance. Here we review the current understanding of influenza virus-specific CD8+ T cell immunity in experimental mouse models and humans. The characteristics and nature of CD8+ T cell killing are discussed, as is the selection and maintenance of the influenza-specific effector and memory repertoires. Consideration is given to vaccine strategies and to the effects of ageing. Understanding the complexities of CD8+ T cell mediated immunity and memory has the potential for improving vaccine design, particularly to combat pandemics caused by newly emerging influenza viruses. (C) 2008 Elsevier Inc. All rights reserved.
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