期刊
PHARMACOLOGICAL REVIEWS
卷 60, 期 4, 页码 405-417出版社
AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
DOI: 10.1124/pr.108.00802
关键词
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资金
- Biotechnology and Biosciences Research Council [BB/E006302/1]
- National Health and Medical Research Council/National Heart Foundation of Australia
- BBSRC [BB/E006302/1, BB/E019455/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E006302/1, BB/E019455/1] Funding Source: researchfish
Identification of G protein-coupled receptors that are activated by free fatty acids has led to considerable interest in their pharmacology and function because of the wide range of normal physiology and disease states in which fatty acids have been implicated. Free fatty acid receptor ( FFA) 1 is activated by medium- to long-chain fatty acids and is expressed in the insulin-producing beta-cells of the pancreas. Activation of FFA1 has been proposed to mediate fatty acid augmentation of glucose-stimulated insulin secretion although it is unclear whether the known long-term detrimental effects of beta-cell exposure to high levels of fatty acids are also mediated through this receptor. The related receptors FFA2 and FFA3 are both activated by short-chain fatty acids although they have key differences in the signaling pathways they activate and tissue expression pattern. The aim of this review is to provide a comprehensive overview of the current understanding of the pharmacology and physiological role of these fatty acid receptors.
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