期刊
PHARMACOLOGICAL RESEARCH
卷 63, 期 2, 页码 102-107出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2010.10.004
关键词
Protease inhibitors; Doxycycline; Minocycline
资金
- NCCIH NIH HHS [R21 AT004277, R21 AT004277-02S1, R21 AT004277-01A2] Funding Source: Medline
- NHLBI NIH HHS [R01 HL043617-10A2, T32 HL007444, R01 HL043617] Funding Source: Medline
- NIMHD NIH HHS [P60 MD000220, P60 MD000220-06] Funding Source: Medline
Tetracyclines were developed as a result of the screening of soil samples for antibiotics. The first(t) of these compounds, chlortetracycline, was introduced in 1947. Tetracyclines were found to be highly effective against various pathogens including rickettsiae, as well as both gram-positive and gram-negative bacteria, thus becoming the first class of broad-spectrum antibiotics. Many other interesting properties, unrelated to their antibiotic activity, have been identified for tetracyclines which have led to widely divergent experimental and clinical uses. For example, tetracyclines are also an effective anti-malarial drug. Minocycline, which can readily cross cell membranes, is known to be a potent anti-apoptotic agent. Another tetracycline, doxycycline is known to exert anti-protease activities. Doxycycline can inhibit matrix metalloproteinases which contribute to tissue destruction activities in diseases such as periodontitis. A large body of literature has provided additional evidence for the beneficial actions of tetracyclines, including their ability to act as reactive oxygen species scavengers and anti-inflammatory agents. This review provides a summary of tetracycline's multiple mechanisms of action as a means to understand their beneficial effects. (C) 2010 Elsevier Ltd. All rights reserved.
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