期刊
PHARMACOLOGICAL RESEARCH
卷 59, 期 6, 页码 365-378出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2009.01.017
关键词
Cancer; Natural compounds; Cancer therapy; Cancer chemoprevention
资金
- MIUR
- AIRC
- Ente Cassa di Risparmio di Firenze
- Fondazione Cassa di Risparmio di Lucca
- Associazione Giacomo Onlus
We describe here the main natural compounds used in cancer therapy and prevention, the historical aspects of their application and pharmacognosy. Two major applications of these compounds are described: as cancer therapeutics and as chemopreventive compounds. Both natural compounds, extracted from plants or animals or produced by microbes (antibiotics), and synthetic compounds, derived from natural prototype structures, are being used. We also focus on the molecular aspects of interactions with their recognized cellular targets, from DNA to microtubules. Some critical aspects of current cancer chemotherapy are also discussed, focusing on genetics and genomics, and the recent revolutionary theory of cancer: aneuploidy as the primum movens of cancer. (C) 2009 Elsevier Ltd. All rights reserved.
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