期刊
TUMOR BIOLOGY
卷 37, 期 2, 页码 1559-1565出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-4690-6
关键词
Cancer stem cell; CXCR4/CXCL12 axis; Nanog; NF-kappa B; Directed cell migration; Metastasis; Stemness
类别
资金
- Ferdowsi University of Mashhad, Mashhad, Iran [3/25064]
- Council for Stem Cell Sciences and Technologies of Iran [100311]
- Research Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
Directed cell migration is a crucial mobility phase of cancer stem cells having stemness and tumorigenic characteristics. It is known that CXCR4 plays key roles in the perception of chemotactic gradients throughout the directed migration of CSCs. There are a number of complex signaling pathways and transcription factors that coordinate with CXCR4/CXCL12 axis during directed migration. In this review, we focus on some transcription factors such as Nanog, NF-kappa B, and Bmi-1 that cooperate with CXCR4/CXCL12 for the maintenance of stemness and induction of metastasis behavior in cancer stem cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据