期刊
PHARMACOLOGICAL REPORTS
卷 62, 期 6, 页码 1218-1224出版社
SPRINGER HEIDELBERG
DOI: 10.1016/S1734-1140(10)70385-6
关键词
maternal separation; NCAM; substantia nigra; ventral tegmental area; medial prefrontal cortex; nucleus accumbens; striatum; Western blot
资金
- Ministry of Science and Higher Education, Warszawa, Poland [N401 154 31/3361]
- statutory activity of Institute of Pharmacology, Polish Academy of Sciences, Krakow
Stressful experiences in the early stages of life can influence brain development and maturation, and they can also increase the risk for some psychiatric disorders; however, the specific mechanisms of this effect are still poorly understood. Neural cell adhesion molecules (NCAM 120, 140, 180 kDa) are known to play an important role in normal brain development and synaptic plasticity. Therefore, we decided to investigate whether maternal separation (MS) in rats, a paradigm which models an early life stress, has any impact on the expression of NCAM proteins in the juvenile, adolescent and adult brains of both male and female rats. Specifically, we focused our efforts on the brain regions associated with dopaminergic neurotransmission. In juvenile rats, MS decreased the levels of NCAM-140 in the substantia nigra (SN) of females and NCAM-180 in the ventral tegmental area of males. During adolescence, a reduction in NCAM-180 levels in the SN and medial prefrontal cortex (mPFC) of MS females was revealed. Finally, in adulthood, a decrease in NCAM-180 expression was observed in the mPFC of MS males. The results that we obtained indicate that early life stress can affect maturation and NCAM-driven plasticity in dopaminergic brain areas at different stages of ontogenesis and with a sex-specific manner.
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