期刊
TUMOR BIOLOGY
卷 37, 期 4, 页码 5437-5443出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-4377-z
关键词
Ovarian cancer; microRNAs; miR-761; Musashi1
类别
Increasing evidences have revealed that microRNAs regulate various biological processes. However, the roles of miR-761 have not been investigated in ovarian cancer. Here, we found that miR-761 expression was significantly lower in ovarian cancer tissues than in their paired noncancerous tissues. Further study revealed that miR-761 overexpression inhibited the ovarian cancer cell proliferation and invasion. Mechanistically, we demonstrated that the oncogenic properties of miR-761 in ovarian cancer were mediated in part by regulating MSI1 expression. miR-761 and MSI1 are inversely expressed in ovarian cancer tissues. In conclusion, we demonstrated that miR-761 repressed ovarian cancer proliferation and invasion by targeting MSI1.
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