期刊
TUMOR BIOLOGY
卷 37, 期 5, 页码 5941-5949出版社
SPRINGER
DOI: 10.1007/s13277-015-4409-8
关键词
Melanoma; miR-125b; ITGA9; EMT; Invasion
类别
资金
- Jiangxi Province Science and Technology Support Program [20141BBG70024]
- Jiangxi Province Postdoctoral Science Foundation [2015KY20]
- China Postdoctoral Science Foundation [2015M582048]
Increasing evidence has shown that aberrant miRNAs contribute to the development and progression of human melanoma. Previous studies have shown that miR-125b functions as a suppressor in malignant melanoma. However, the molecular function and mechanism by which miR-125b influences melanoma growth and invasion are still unclear. In this study, we aimed to investigate the role of miR-125b in melanoma progression and metastasis. We found that miR-125b expression is significantly downregulated in primary melanoma, and an even greater downregulation was observed in metastatic invasion. Restored expression of miR-125b in melanoma suppressed cell proliferation and invasion both in vitro and in vivo. Furthermore, our findings demonstrate that upregulating miR-125b significantly inhibits malignant phenotypes by repressing the expression of integrin alpha9 (ITGA9). Finally, our data reveal that upregulated expression of ITGA9 in melanoma tissues is inversely associated with miR-125b levels. Together, our results demonstrate that upregulation of ITGA9 in response to the decrease in miR-125b in metastatic melanoma is responsible for melanoma tumor cell migration and invasion.
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