期刊
TUMOR BIOLOGY
卷 37, 期 1, 页码 999-1008出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-3875-3
关键词
Hepatocellular carcinoma; Clusterin; Diagnosis; Prognosis
类别
资金
- Chinese National Natural Science Foundation [81200634]
- Nantong Society Development [HS2014078]
- Jiangsu Health Projects [BL2012053, YY-028, K201102, WSN-078]
- Priority Academic Program Development of Jiangsu (PADA)
- International S&T Cooperation Program of China [2013DFA32150]
The upregulation of secretory clusterin (sCLU) is associated with tumor progression by contributing to angiogenesis, chemo-resistance, cell survival, and metastasis. However, its diagnostic or prognostic values for hepatocellular carcinoma (HCC) still remain to be clarified. The average serum sCLU level analyzed by an enzyme-linked immunosorbent assay was significantly higher (P < 0.001) in HCC patients than that in any of cases with cirrhosis, chronic hepatitis, or healthy control. The area under receiver operating characteristic curve and diagnostic sensitivity were 0.75 and 74.7 % in sCLU, and 0.74 and 58.7 % in alpha-fetoprotein (AFP), respectively. The combining detections of sCLU and AFP rose up to 90.7 % for HCC diagnosis. In liver, sCLU by immunohistochemistry was significantly higher (P < 0.001) in the HCC (77.3 %) group than that in their para-cancerous group (33.3 %). Abnormal serum or tissue sCLU expression was closely associated with tumor-node-metastasis (TNM) classification of malignant tumors and lymph node metastasis, as an independent prognosis factor (hazard ratio, 2.287; 95 % confidence interval, 1.044-5.007; P = 0.039), and higher sCLU expression significantly correlated (chi (2) = 4.252, P = 0.039) with poor survival of HCC patients analyzed by multivariate Cox regression or Kaplan-Meier method, suggesting that abnormal sCLU expression associated with tumor progression could be a potential diagnostic and prognostic biomarker for HCC.
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