期刊
PHARMACOGENOMICS
卷 10, 期 2, 页码 181-190出版社
FUTURE MEDICINE LTD
DOI: 10.2217/14622416.10.2.181
关键词
association; family; genome-wide association study; GWAS; SNPs; TDT; Transmission Disequilibrium Test
资金
- National Health and Medical Research Council, Australia
In the last 2 years, the effort to identify genes affecting common diseases and complex traits has been accelerated through the use of genome-wide association studies (GWAS). The availability of existing large collections of linkage data paved the way for the use of family-based GWAS. Although most published GWAS used population-based designs, family-based designs have played an important role, particularly In replication stages. Family-based designs offer advantages in terms of quality control, the robustness to population stratification and the ability to perform genetic analyses that cannot be achieved using a sample of unrelated individuals, such as testing for the effect of imprinted genes on phenotypes, testing whether a genetic variant is inherited or de novo and combined linkage and association analysis.
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