期刊
PHARMACOGENOMICS
卷 10, 期 11, 页码 1819-1837出版社
FUTURE MEDICINE LTD
DOI: 10.2217/PGS.09.121
关键词
association studies; genetics; hepatitis C; spontaneous hepatitis C clearance
资金
- Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Diseases
- NIH [DA13324]
Acute infection with the hepatitis C virus (HCV) induces a wide range of innate and adaptive immune responses. A total of 20-50% of acutely HCV-infected individuals permanently control the virus, referred to as 'spontaneous hepatitis C clearance', while the infection progresses to chronic hepatitis C in the majority of cases. Numerous studies have examined host genetic determinants of hepatitis C infection outcome and revealed the influence of genetic polymorphisms of human leukocyte antigens, killer immunoglobulin-like receptors, chemokines, interleukins and interferon-stimulated genes on spontaneous hepatitis C clearance. However, most genetic associations were not confirmed in independent cohorts, revealed opposing results in diverse populations or were limited by varying definitions of hepatitis C outcomes or small sample size. Coordinated efforts are needed in the search for key genetic determinants of spontaneous hepatitis C clearance that include well-conducted candidate genetic and genome-wide association studies, direct sequencing and follow-up functional studies.
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