期刊
PHARMACEUTICAL STATISTICS
卷 11, 期 2, 页码 135-140出版社
WILEY
DOI: 10.1002/pst.514
关键词
mean survival; restricted mean survival; extrapolation; variance estimate; quality-adjusted lifetime
Asymptotic distribution of the mean survival time based on the KaplanMeier curve with an extrapolated tail is derived. A closed formula of the variance estimate is provided. Asymptotic properties of the estimator were studied in a simulation study, which showed that this estimator was unbiased with proper coverage probability and followed a normal distribution. An example is used to demonstrate the application of this estimator. Copyright (c) 2012 John Wiley & Sons, Ltd.
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