期刊
TUMOR BIOLOGY
卷 37, 期 3, 页码 3489-3496出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-4188-2
关键词
Facial lymph node; Oral squamous cell carcinoma; Neck dissection; Surgery; Postoperative radiotherapy
类别
资金
- Science & Technology support program from Hunan Provincial Science & Technology Department [2013SK3204]
- Health Department of Hunan Province [B2013-091]
- Science Foundation for Distinguished Young Scholars from Hunan Cancer Hospital [A2011-04]
To investigate the incidence of metastasis to facial lymph nodes (FLNs) and to determine its impact on the prognosis and survival of patients at onset of oral cavity squamous cell carcinoma (OSCC). A retrospective review of 641 patients with OSCC treated with curative surgery (CS) alone or CS + postoperative radiotherapy (PORT) was performed. Based on FLN status, an analysis of clinicopathologic parameters, prognosis, and survival was conducted. By classifying patients according to FLN status, a reasonable treatment modality was identified in the low-risk group, which was defined as those who had N0-1 disease, negative margin, and no extracapsular nodal spread (ENS). FLN involvement was identified in 103 patients (16 %), which showed statistically significant associations with several established risk factors and negatively affected local controls (P < 0.001), neck controls (P < 0.001), and disease-specific survival (P < 0.001). Compared to CS alone, CS + PORT increased the 5-year neck control rate (76.8 vs. 30.7 %, P = 0.006) and disease-specific survival rate (67.8 vs. 30.7 %, P = 0.037) of the OSCC patients with FLN metastasis in the low-risk group. Metastasis to FLNs is strongly associated with poor disease control and lower survival rate of OSCC patients. PORT minimized the residual risk of involved FLN in the low-risk group.
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