期刊
PHARMACEUTICAL RESEARCH
卷 31, 期 6, 页码 1485-1500出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-013-1255-5
关键词
drug release; kinetic stability; poly ethylene oxide; poly lactic acid; polymeric micelle
资金
- Natural Science and Engineering Council of Canada (NSERC)
To investigate the effect of polymerization method on the stability and drug release properties of polymeric micelles formed using stereo-active block copolymers. Diblock copolymers consisting of methoxy poly ethylene oxide (MePEO) and poly(lactide)s (PLA)s of different stereochemistry were synthesized by bulk or solution polymerization. Polymers and micelles were characterized for their chemical structure by H-1 NMR, optical rotation by polarimetry, critical micellar concentration by fluorescence spectroscopy, thermal properties by differential scanning calorimetry, morphology by transmission electron microscopy and size as well as kinetic stability by dynamic light scattering. Release of encapsulated nimodipine from polymeric micelles at different levels of loading was also investigated. Solution polymerization yielded a higher degree of crystallinity for stereo-regular PLA blocks. Consequently, the related polymeric micelles were kinetically more stable than those prepared by bulk polymerization. At high drug loading levels, the release of nimodipine was more rapid from polymeric micelles with crystalline cores. At lower levels of drug loading, drug release was slower and independent of the stereochemistry of the core. The results underline the effect of polymerization method in defining core crystallinity in stereoregular block copolymer micelles. It also shows the impact of core crystallinity on enhancing micellar stability and drug release.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据