期刊
PHARMACEUTICAL RESEARCH
卷 30, 期 12, 页码 3186-3199出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-013-1106-4
关键词
SEDDS; Porous silicate; Neusilin (R) US2; Tablets; Powder properties; Tensile strength; Dispersion test; Gel formation
资金
- ABITEC Corporation, Columbus, OH, USA
To develop tablet formulations by adsorbing liquid self-emulsifying drug delivery systems (SEDDS) onto NeusilinA (R) US2, a porous silicate. Nine SEDDS were prepared by combining a medium chain monoglyceride, Capmul MCM EP, a medium chain triglyceride, Captex 355 EP/NF, or their mixtures with a surfactant Cremophor EL, and a model drug, probucol, was then dissolved. The solutions were directly adsorbed onto NeusilinA (R) US2 at 1:1 w/w ratio. Content uniformity, bulk and tap density, compressibility index, Hausner ratio and angle of repose of the powders formed were determined. The powders were then compressed into tablets. The dispersion of SEDDS from tablets was studied in 250 mL of 0.01NHCl (USP dissolution apparatus; 50 RPM; 37A degrees C) and compared with that of liquid SEDDS. After adsorption of liquid SEDDS onto NeusilinA (R) US2, all powders demonstrated acceptable flow properties and content uniformity for development into tablet. Tablets with good tensile strength (> 1 MPa) at the compression pressure of 45 to 135 MPa were obtained. Complete drug release from tablets was observed if the SEDDS did not form gels in contact with water; the gel formation clogged pores of the silicate and trapped the liquid inside pores. Liquid SEDDS were successfully developed into tablets by adsorbing them onto NeusilinA (R) US2. Complete drug release from tablets could be obtained.
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