期刊
PHARMACEUTICAL RESEARCH
卷 29, 期 11, 页码 2943-2971出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-012-0828-z
关键词
antimitotic; cancer; colchicine; multidrug resistance; tubulin polymerization inhibitor
资金
- National Cancer Institute of the National Institutes of Health [R01CA148706]
Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine binding site is one of the most important pockets for potential tubulin polymerization destabilizers. Colchicine binding site inhibitors (CBSI) exert their biological effects by inhibiting tubulin assembly and suppressing microtubule formation. A large number of molecules interacting with the colchicine binding site have been designed and synthesized with significant structural diversity. CBSIs have been modified as to chemical structure as well as pharmacokinetic properties, and tested in order to find a highly potent, low toxicity agent for treatment of cancers. CBSIs are believed to act by a common mechanism via binding to the colchicine site on tubulin. The present review is a synopsis of compounds that have been reported in the past decade that have provided an increase in our understanding of the actions of CBSIs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据