期刊
PHARMACEUTICAL RESEARCH
卷 27, 期 8, 页码 1439-1468出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-010-0117-7
关键词
agonist; antagonist; ligand binding domain; orphan nuclear receptor
资金
- Damon Runyon Clinical Investigator Award [CI015-02]
- NCI [1R01CA127231-01]
- Albert Einstein College of Medicine, Bronx, NY
Orphan nuclear receptors regulate diverse biological processes. These important molecules are ligand-activated transcription factors that act as natural sensors for a wide range of steroid hormones and xenobiotic ligands. Because of their importance in regulating various novel signaling pathways, recent research has focused on identifying xenobiotics targeting these receptors for the treatment of multiple human diseases. In this review, we will highlight these receptors in several physiologic and pathophysiologic actions and demonstrate how their functions can be exploited for the successful development of newer drugs.
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