期刊
ACTA HISTOCHEMICA ET CYTOCHEMICA
卷 48, 期 3, 页码 75-81出版社
JAPAN SOC HISTOCHEMISTRY & CYTOCHEMISTRY
DOI: 10.1267/ahc.14054
关键词
EphA7; esophageal squamous cell carcinoma; lymph mode metastasis; immunohistochemistry; prognosis
类别
资金
- National Basic Research Program (973 Program) [2012CB526608]
- Inner Mongolia Autonomous Region Natural Science Foundation [2013MS1113]
- Natural Science Foundation of China [81201844, 81360331]
- scientific research and innovation team building program of Chifeng University
As a member of the Eph family of receptor tyrosine kinases, EphA7 plays an important role in cancer. However, the expression and significance of Eph receptors in esophageal squamous cell carcinoma (ESCC) remain unclear. Here, we detected the expression of EphA7 by immunohistochemistry in a sample of 352 patients with ESCC, and aimed to investigate the expression status of EphA7 in ESCC and its impact on prognosis. The results showed that low EphA7 expression significantly correlated with lymph node metastases (N0: 29%; N1: 64%. p<0.001), poor degree of tumor differentiation (G1: 31%; G2: 49%; G3: 58%. p=0.009) and pTNM staging (I+II: 33%; III+IV: 58%. p<0.001). Furthermore, in a combined analysis, patients with low EphA7-expressing tumors showed a shorter overall survival than those with high expression, resulting in a five-year overall survival rate of 47.4% vs. 52.6%, respectively (p=0.016). Consequently, patients with a low EphA7 expression have poorer prognosis in ESCC compared with those manifesting high expression.
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