4.4 Article

Diffusion of uncharged solutes through human nail plate

期刊

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
卷 21, 期 2, 页码 255-260

出版社

TAYLOR & FRANCIS LTD
DOI: 10.3109/10837450.2014.991876

关键词

Corneocyte permeability; fiber matrix model; nail permeability; onychomycosis; passive diffusion; transungual drug delivery

资金

  1. National Institutes of Health (NIH) [GM063559]
  2. Div Of Chem, Bioeng, Env, & Transp Sys
  3. Directorate For Engineering [1335822] Funding Source: National Science Foundation

向作者/读者索取更多资源

Passive diffusion data for uncharged solutes in hydrated human nail plate are collected and compared to the predictions of two theories for diffusion of uncharged solutes in dense keratin matrices. Quantitative agreement between the experimental data and the theories examined is poor. Concerns with both the experiments and the theories are identified and discussed. It is evident from the analysis that magnitude of the experimental nail permeability data may be questioned, as may the extrapolation procedures used to estimate the properties of dense fiber arrays from more dilute systems. Despite these caveats, it can be inferred that the microstructure of the nail plate is more complex than that assumed in the described models. The influence of residual lipids is implicated. More rigorous experiments and theoretical analysis of mass transport in the nail plate system are warranted. Successful completion of these tasks could lead not only to better predictions of transungual drug delivery, but also to better models of skin permeability, if hydrated nail plate can indeed serve as a model for the corneocyte phase of (partially hydrated) stratum corneum.

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