期刊
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
卷 16, 期 4, 页码 287-294出版社
INFORMA HEALTHCARE
DOI: 10.3109/10837450.2010.485320
关键词
Spray drying; submicron particles; vibrating mesh; electrostatic particle collector; nano spray dryer
The vibrating mesh spray technology implemented in the Nano Spray Dryer B-90 was evaluated for pharmaceutical applications by spray drying common pharmaceutical excipients (e. g. trehalose, mannitol) and model drugs (e. g. griseofulvin). Aerosol droplet size measurements investigated the influence of spray solution factors (e. g. viscosity, surface tension) and of vibrating mesh aperture sizes on particle characteristics. Particle deposition on the spray nozzle was addressed by analyzing the influence of spray solute concentration and solvent on the process outcome. Submicron particles with 0.5 mu m and 0.8 mu m mean particle size were obtained at high yields for 50 mg powder amounts.
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