期刊
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
卷 15, 期 5, 页码 532-544出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10837450903338379
关键词
Ciprofloxacin; norfloxacin; stability; metal ions; TLC
资金
- State Committee for Scientific Research of Poland [2P05F02527]
A thin-layer chromatographic-densitometric method was used to determine the stability of ciprofloxacin and norfloxacin in the presence and absence of metal ions in acidic solutions at 22 C, 50 C and 90 C. The degradation of ciprofloxacin and norfloxacin followed first order reaction kinetics in presence of metal ions. The extent of this degradation however depended on the type of metal ion and temperature. Product structures of ciprofloxacin (1-cyclopropyl-6-fluoro-7-(piperazin-1-yl)quinolin-4(1H)-one) and norfloxacin (1-ethyl-6-fluoro-7-(piperazin-1-yl) quinolin-4(1H)-one) were determined by analysis of UV spectra and using LC-MS method.
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