期刊
PHARMACEUTICAL CHEMISTRY JOURNAL
卷 46, 期 3, 页码 165-170出版社
SPRINGER
DOI: 10.1007/s11094-012-0752-x
关键词
2-thioxoimidazolidin-4-one; 2-thiohydantoin; arylidine; styryl; anti-HIV; HIV-1; HIV-2
资金
- University Grants Commission (New Delhi) [30 - 60/2004(SR)]
1,3-Bis{(2-thiophene-2-yl)ethyl}-5-(arylidine)-2-thioxoimidazolidin-4-ones (5a - 5 m) have been synthesized by condensation of 1,3-diarylalkyl-2-thiohydantoin (4) with various aromatic aldehydes. Compound (4) was prepared by the reaction of 1,3-bis (2-thien-2-yl-ethyl)-thiourea (3) with chloroacetic acid. The synthesized compounds have been tested for their anti-HIV-1 and -2 effects, but did not show any specific anti-HIV activity. The structures of newly synthesized compounds were established on the basis of elemental analyses, (1) H NMR, IR and mass spectrometry data.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据