期刊
TUBERCULOSIS
卷 95, 期 3, 页码 246-250出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2015.03.006
关键词
Mycobacterium tuberculosis; microRNA; miR-155
资金
- Grants for International Health Research from the Ministry of Health, Labor, and Welfare of Japan [27A-1102, 26A-103, 24A-93103]
- Grants-in-Aid for Scientific Research [25860331] Funding Source: KAKEN
MicroRNAs (miRNAs) are short, conserved, non-coding RNA molecules that repress translation, followed by the decay of miRNA-targeted mRNAs that encode molecules involved in cell differentiation, development, immunity and apoptosis. At least six miRNAs, including microRNA-155 (miR-155), were upregulated when born marrow-derived macrophages from C57BL/6 mice were infected with Mycobacterium tuberculosis Erdman. C57BL/6 mice intravenously infected with Erdman showed up-regulation of miR-155 in livers and lungs. Following infection, miR-155-deficient C57BL/6 mice died significantly earlier and had significantly higher numbers of CFU in lungs than wild-type mice. Moreover, fewer CD4(+) T cells, but higher numbers of monocytes and neutrophils, were present in the lungs of Erdman-infected miR-155 knockout (miR-155(-/-)) than of wild-type mice. These findings indicated that miR-155 plays a critical role in immune responses to M. tuberculosis. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据