期刊
PHARMACEUTICAL BIOLOGY
卷 49, 期 6, 页码 583-586出版社
INFORMA HEALTHCARE
DOI: 10.3109/13880209.2010.529616
关键词
monoterpene; alpha-terpineol; pain; formalin; glutamate; capsaicin
资金
- Fundacao de Apoio a Pesquisa e a Inovacao Tecnologica do Estado de Sergipe/FAPITEC-SE/Brazil [019.203.00860/2009-6]
Context: alpha-Terpineol (TPN) is a monoterpenoid alcohol present in the essential oils of several species of the Eucalyptus genus (Myrtaceae). Objective: TPN was assessed for its antinociceptive activity in rodents. Materials and methods: The antinociceptive effect of TPN was examined using the acetic acid writhing reflex, formalin, glutamate, and capsaicin-induced nociception tests. Results: TPN produced a significant (P < 0.01 or P < 0.001) analgesic effect by reduction at the early and late phases of paw licking and reduced the writhing reflex in mice (formalin and writhing tests, respectively). In the glutamate test, all doses of TPN produced significant (P < 0.01) nociceptive protection. When the capsaicin-induced nociception test was conducted, TPN produced dose-related inhibition of the nociceptive behavior. In addition, the results of a hot plate test showed central analgesic properties for TPN (P < 0.01 or P < 0.001). Such results were unlikely to be provoked by motor abnormality. Conclusion: Our results suggest that TPN might represent an important tool for management and/or treatment of painful conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据