期刊
PHARMACEUTICAL BIOLOGY
卷 48, 期 8, 页码 861-868出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/13880200903302820
关键词
Alpinia conchigera; antinociceptive; anti-inflammatory; opioid receptor
资金
- Ministry of Higher Education, Malaysia [FRGS/FASA1-2006/(Sains Perubatan)/UPM/179]
Alpinia conchigera Griff. (Zingiberaceae), locally known to the Malays as lengkuas ranting, is native to Peninsular Malaysia. The Malays traditionally used it to treat infection and rashes, and as a health drink. This study evaluated the analgesic and anti-inflammatory activities of the ethanol extract of A. conchigera rhizomes in mice and rats, respectively. The analgesic activity was elucidated using the acetic acid-induced writhing test, hot plate test, and formalin test, while the anti-inflammatory activity was determined using carrageenan-induced paw edema. The extract (30, 100, and 300 mg/kg) given intraperitoneally (i.p.) exhibited antinociceptive and anti-inflammatory activities in all tests used. The range of percentage of analgesia obtained for all doses of extract in the writhing test was 50-92%, and in the early and late phases of the formalin test was 25-62% and 63-98%, respectively. In addition, naloxone (5 mg/kg) given subcutaneously (s.c.) was found to reverse the extract (300 mg/kg)-induced antinociceptive activity in the writhing, hot plate, and formalin tests. Based on the results obtained, it can be concluded that the ethanol extract of A. conchigera rhizomes possessed a peripheral and central antinociceptive activity that was mediated, in part, via the opioid receptor, as well as anti-inflammatory activity.
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