期刊
PHARMACEUTICAL BIOLOGY
卷 48, 期 7, 页码 745-752出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/13880200903273914
关键词
Anti-inflammatory activity; antinociceptive activity; antioxidant potential; Cladonia clathrata; lichen
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq - PIBIC/CNPq/UFS)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Cladonia clathrata Ahti & L. Xavier-Filho (Cladoniaceae) is a lichen; several Cladonia species extracts have been used for various remedies in folk medicine. In order to evaluate the actions of this lichen, studies were performed on antinociceptive, anti-inflammatory, and antioxidant activities. The hydroalcoholic extract (HE) of C. clathrata stems was used in the following experiments. Oral treatment with the HE of C. clathrata elicited inhibitory activity (p < 0.001) on acetic acid-induced abdominal writhes at 100 (47.2%), 200 (47.2%), and 400 mg/kg (86.4%), and reduced the formalin-induced nociception on both the neurogenic (400 mg/kg, p < 0.01) and inflammatory phases (200 and 400 mg/kg, p < 0.01). It was not associated with non-specific effects, such as muscle relaxation or sedation. The HE reduced the carrageenan-induced edema formation at 100, 200, and 400 mg/kg (p < 0.05) and inhibited neutrophil migration into the peritoneal cavity at 400 mg/kg (p < 0.001). The HE of C. clathrata reacted with the DPPH radical and reduced the same by 50.19%, and exhibited an IC50 value of 69.25 +/- 0.65 mu g/mL. The HE of C. clathrata stems shows antinociceptive and anti-inflammatory activities, with a moderate antioxidant potential.
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