期刊
PHARMACEUTICAL BIOLOGY
卷 47, 期 1, 页码 53-60出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13880200802415483
关键词
Anthrax; antimicrobial; brine shrimp; cyanobacteria; protease inhibition; proteasome; SARS; tuberculosis
资金
- NIH [1 R01 GM075856]
- University of Illinois at Chicago Spring 2006 Provost Award
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM075856] Funding Source: NIH RePORTER
A culture collection of cyanobacteria has been established at the University of Illinois at Chicago. This collection includes marine, terrestrial, and freshwater strains and contains representatives of the five orders of cyanobacteria: Chroococcales, Pleurocapsales, Oscillatoriales, Nostocales, and Stigonematales. In this study, extracts from a subset of 61 strains, 16 marine and 45 freshwater/terrestrial, were evaluated against three current protease targets, i.e. 20S proteasome and two SARS viral proteases, two important bacterial targets, i.e. Mycobacterium tuberculosis and Bacillus anthracis, and in the Artemia salina toxicity assay. In total, extracts of 12 strains possessed significant levels of activity in one or more targets. The overwhelming majority of active extracts (111 of 12) were from either freshwater or terrestrial forms of cyanobacteria, with the greater part of these (9 of 12) being heterocyst-forming strains. These results further support the use of cultured cyanobacteria as a source of biologically active natural products.
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