期刊
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
卷 467, 期 1, 页码 175-190出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00424-014-1536-9
关键词
Muscle spindle; Mechanotransduction; DEG/ENaC; PLD-mGluR; Synaptic-like vesicle; Mechanosensation
类别
资金
- MRC [G0601253] Funding Source: UKRI
- Medical Research Council [G0601253] Funding Source: researchfish
- Medical Research Council [G0601253] Funding Source: Medline
The focus of this review is on the principal sensory ending of the mammalian muscle spindle, known as the primary ending. The process of mechanosensory transduction in the primary ending is examined under five headings: (i) action potential responses to defined mechanical stimuli-representing the ending's input-output properties; (ii) the receptor potential-including the currents giving rise to it; (iii) sensory-terminal deformation-measurable changes in the shape of the primary-ending terminals correlated with intrafusal sarcomere length, and what may cause them; (iv) putative stretch-sensitive channels-pharmacological and immunocytochemical clues to their identity; and (v) synaptic-like vesicles-the physiology and pharmacology of an intrinsic glutamatergic system in the primary and other mechanosensory endings, with some thoughts on the possible role of the system. Thus, the review highlights spindle stretch-evoked output is the product of multi-ionic receptor currents plus complex and sophisticated regulatory gain controls, both positive and negative in nature, as befits its status as the most complex sensory organ after the special senses.
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