期刊
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
卷 465, 期 6, 页码 767-773出版社
SPRINGER
DOI: 10.1007/s00424-013-1263-7
关键词
Pericyte; Mesangial cell; Renal arteriole; Renin; Kidney fibrosis; Stem cell; Blood pressure regulation; Kidney development
类别
资金
- British Heart Foundation Centre of Research Excellence Award
- BHF
- MRC [G1000816] Funding Source: UKRI
- Medical Research Council [G0700711B] Funding Source: researchfish
Pericytes have become a hot topic in renal biology. They play a critical physiological role in vessel development, maintenance and remodelling through active communication with their vascular partners-endothelial cells-and modulation of extracellular matrix proteins. Multiple functions for renal pericytes have been described; specialised perivascular populations participate in glomerular filtration, regulate medullary blood flow and contribute to kidney fibrosis by differentiation into collagen-generating myofibroblasts. Interestingly, the origin of renin-producing cells of the juxtaglomerular region is attributed to the perivascular cell lineage; we have observed the coincidence of renin and pericyte marker expression during human kidney development. Finally, pericytes have been shown to share features with mesenchymal stem cells, which places them as potential renal progenitor cell candidates. Since renal diseases are often associated with microvascular complications, renal pericytes may emerge as new targets for the treatment of kidney disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据