期刊
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
卷 465, 期 1, 页码 167-175出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00424-012-1096-9
关键词
Obesity; Metabolism; Energy homeostasis; Thermogenesis
类别
资金
- US National Institutes of Health [HL098276, HL014388, HL084207, HL048058, HL061446]
- American Diabetes Association [1-11-BS-127]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL048058, P01HL084207, P01HL014388, K99HL098276, R01HL061446, R37HL048058, R00HL098276] Funding Source: NIH RePORTER
Substantial evidence supports a role for the renin-angiotensin system (RAS) in the regulation of metabolic function, but an apparent paradox exists where genetic or pharmacological inhibition of the RAS occasionally has similar physiological effects as chronic angiotensin infusion. Similarly, while RAS targeting in animal models has robust metabolic consequences, effects in humans are more subtle. Here, we review the data supporting a role for the RAS in metabolic rate regulation and propose a model where the local brain RAS works in opposition to the peripheral RAS, thus helping to explain the paradoxically similar effects of RAS supplementation and inhibition. Selectively modulating the peripheral RAS or brain RAS may thus provide a more effective treatment paradigm for obesity and obesity-related disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据