期刊
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
卷 462, 期 1, 页码 39-48出版社
SPRINGER
DOI: 10.1007/s00424-011-0964-z
关键词
Heart; Stretch; Positive inotropic response; Cardiac mechanics; Mechanosensitivity
类别
资金
- British Heart Foundation
- British Heart Foundation [PG/09/031/27221] Funding Source: researchfish
This paper briefly recapitulates the Frank-Starling law of the heart, reviews approaches to establishing diastolic and systolic force-length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called 'Frank-Starling Gain', calculated as the ratio of slopes of end-systolic and end-diastolic force-length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank-Starling Gain for the comparison of cell contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.
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