期刊
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
卷 459, 期 5, 页码 657-669出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00424-010-0784-6
关键词
Ion channels; Inflammation; Pain; Nociception
类别
资金
- Wellcome Trust
- MRC
- BBSRC
- Royal Society
- MRC [G0700966] Funding Source: UKRI
- Medical Research Council [G0700966] Funding Source: researchfish
Inflammatory pain results from the increased excitability of peripheral nociceptive sensory fibres produced by the action of inflammatory mediators. This excitatory effect, in turn, is a result of the altered activity of ion channels within affected sensory fibres. This review will consider the molecular consequences of inflammation within the peripheral nerves with particular focus on the effects of different inflammatory mediators on the ion channels in sensory neurons. We will discuss the main signalling pathways triggered in neurons by inflammatory mediators; the ionic mechanisms underlying inflammatory hyperalgesia and spontaneous inflammatory pain and finally will briefly consider ion channels underlying pain in chronic inflammation.
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