期刊
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
卷 460, 期 3, 页码 571-581出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00424-010-0847-8
关键词
Cation channel; Mechano-electrical transduction; Mechanoreceptor; Mechanosensitive channel; Transient receptor potential
类别
资金
- ANR 2005 cardiovasculaire-obesite-diabete
- ANR 2008 du gene a la physiopathologie
- Association for information and research on genetic kidney disease France
- Fondation del Duca
- Human Frontier Science Program Organization
- Fondation de la recherche medicale
- Fondation de France
- Fondation de recherche sur l'hypertension arterielle
- Federation pour la recherche sur le cerveau
- Societe Generale AM
- Universite of Nice Sophia Antipolis
- CNRS
Mechano-gated ion channels play a key physiological role in cardiac, arterial, and skeletal myocytes. For instance, opening of the non-selective stretch-activated cation channels in smooth muscle cells is involved in the pressure-dependent myogenic constriction of resistance arteries. These channels are also implicated in major pathologies, including cardiac hypertrophy or Duchenne muscular dystrophy. Seminal work in prokaryotes and invertebrates highlighted the role of transient receptor potential (TRP) channels in mechanosensory transduction. In mammals, recent findings have shown that the canonical TRPC1 and TRPC6 channels are key players in muscle mechanotransduction. In the present review, we will focus on the functional properties of TRPC1 and TRPC6 channels, on their mechano-gating, regulation by interacting cytoskeletal and scaffolding proteins, physiological role and implication in associated diseases.
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