期刊
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
卷 458, 期 6, 页码 1115-1123出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00424-009-0683-x
关键词
Cochlea; Calcium; Hair cell; Stereocilia; TRPP channels; Polycystin; Tip link
类别
资金
- National Institutes on Deafness and other Communication Disorders [RO1 DC01362]
This review summarizes current knowledge of the hair cell mechanotransducer channel, the ion channel responsible for detecting mechanical stimuli in the inner ear and one of the few channels whose molecular structure is still unknown. Several candidate proteins have been proposed, especially members of the transient receptor potential (TRP) channel family, but all have so far failed in one test or another. Furthermore, none has biophysical properties exactly matching the native channel. The defining features of the native mechanotransducer channel are documented, including ionic permeability, channel structure inferred from blocking agents, diversity in channel conductance, and regulation by Ca2+, which are compared with a potential candidate, TRP channels of the polycystin family. The strengths and weaknesses of a TRP channel contender are discussed.
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