期刊
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
卷 114, 期 -, 页码 8-15出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.pestbp.2014.07.011
关键词
Common carp; Cytokine; Immune organ; Atrazine; Chlorpyrifos
资金
- China Postdoctoral Science Foundation [2012M511437]
- Postdoctoral Foundation of Heilongjiang Province [LBH-Z10269]
Atrazine (ATR) and chlorpyrifos (CPF) are toxic and subject to long-term in vivo accumulation in different aquatic species throughout the world. The purpose of the present study was to examine the effect of ATR, CPF and combined ATR/CPF exposure on cytokines in the head kidney and spleen of common carp (Cyprinus carpio L.). The carp were sampled after a 40-d exposure to CPF and ATR, individually or in combination, followed by a 40-d recovery to measure the mRNA expression of IL-6fam (IL-6), IL-8, TNF-alpha, IL-10 and TGF-beta 1 (TGF-beta) in the head kidney and spleen tissues. These results showed that the expression of cytokines IL-6, IL-8 and TNF-alpha in the head kidney and spleen was upregulated following ATR, CPF and mixed ATR/CPF exposure compared with the control group. The expression of IL-10 and TGF-beta mRNA was significantly inhibited in both head kidney and spleen of carp exposed to AIR, CPF and the ATR/CPF mixture. The results suggested that long-term exposure of ATR, CPF and the ATR/CPF mixture in aquatic environments can induce the dysregulation of pro-/anti-inflammatory cytokine expression. The information regarding the effects of ATR and CPF on cytokine mRNA expression generated in this study will be important information for pesticides toxicology evaluation. (C) 2014 Elsevier Inc. All rights reserved.
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