期刊
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
卷 104, 期 2, 页码 103-110出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.pestbp.2012.05.007
关键词
Bacillus thuringiensis; Cry1A toxin; Insect resistance; ABC transporter; Lepidoptera
资金
- Max-Planck-Gesellschaft
Insecticidal crystal toxins from the bacterium Bacillus thuringiensis (Bt) kill insects via a complex mode of action resulting in the creation of cytolytic pores in the membrane of midgut epithelial cells. Recent genetic studies in four species of Lepidoptera have found mutations in an ABC transporter in strains that have evolved resistance to Cry1A toxins. This points to a novel role of ABC proteins in insertion of pores into the membrane, and suggests strategies to increase efficacy of and delay resistance to Bt toxins. (c) 2012 Elsevier Inc. All rights reserved.
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