期刊
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
卷 92, 期 2, 页码 61-69出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.pestbp.2008.06.009
关键词
pyrethroids; synaptosomes; Ca2+ influx; glutamate release; voltage-sensitive calcium channel
The action of 11 commercial pyrethroids on Ca2+ influx and glutamate release was assessed using high-throughput functional assays with rat brain synaptosomes to better understand the mechanistic nature of pyrethroid-induced neurotoxicity and aid in the reassessment of pyrethroids in vivo. Concentration-dependent response curves for each of the non-cyano and alpha-cyano containing pyrethroids were determined and the data used in a cluster analysis. The previously characterized alpha-cyano pyrethroids that induce the CS-syndrome (cypermethrin, deltamethrin, and esfenvalerate) increased Ca2+ influx and glutamate release, and clustered with two other alpha-cyano pyrethroids (beta-cyfluthrin and lambda-cyhalothrin) that shared these same actions. Previously characterized T-syndrome pyrethroids (bioallethrin, cismethrin, and fenpropathrin) did not share these actions and clustered with two other non-cyano pyrethroids (tefluthrin and bifenthrin) that likewise did not elicit these actions. Our current findings indicate that pyrethroids that have an alpha-cyano group (with the exception of fenpropathrin) were more potent enhancers of Ca2+ influx and glutamate release under depolarizing conditions than pyrethroids that did not possess this functional group. The collective data set does not support the hypothesis that pyrethroids, as a class, act in a similar fashion at presynaptic nerve terminals. (C) 2008 Elsevier Inc. All rights reserved.
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