期刊
PEST MANAGEMENT SCIENCE
卷 70, 期 2, 页码 173-178出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/ps.3567
关键词
fungicide; resistance; triazole; Aspergillus fumigatus
资金
- Fungal Infection Trust
- BBSRC
- National Institute of Health Research
- European Union Framework 7
- AstraZeneca
- National Institute of Allergy and Infectious Diseases
- European Union and AstraZeneca
Fungal diseases are problematic in both human health and agriculture. Treatment options are limited and resistance may emerge. The relatively recent recognition of triazole resistance in Aspergillus fumigatus has prompted questioning of the origin of resistance. While multiple mechanisms are described in clinical isolates from triazole-treated patients, some de novo resistance is also recognised, especially attributable to TR34/L98H. Such strains probably arose in the environment, and, indeed, multiple studies have now demonstrated TR34/L98H triazole resistance strains of A. fumigatus from soil. Docking and other in vitro studies are consistent with environmental resistance induction through exposure to certain triazole fungicides, notably difenoconazole, propiconazole, epoxiconazole, bromuconazole and tebuconazole. This article addresses the potential implications of this issue for both human health and food security. (c) 2013 Society of Chemical Industry
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