期刊
PERSONALIZED MEDICINE
卷 9, 期 5, 页码 547-557出版社
FUTURE MEDICINE LTD
DOI: 10.2217/PME.12.55
关键词
gene expression; molecular signatures; radiation therapy; radiosensitivity; systems biology
资金
- NIH (MD, USA) [R21CA101355/R21CA135620]
- US Army Medical Research and Materiel Command (MD, USA)
- National Functional Genomics Center (Moffitt Cancer Center, FL, USA) [170220051]
- Bankhead-Coley Foundation (FL, USA) [09BB-22]
The last two decades have seen technological developments that have led to more accurate delivery of radiation therapy (RT), which has resulted in clinical gains in many solid tumors. However, a fundamental question and perhaps the next major hurdle is whether biological strategies can be developed to further enhance the effectiveness and efficiency of RT. This article addresses the development of a novel genomics-based molecular assay to predict tumor radiosensitivity, and proposes that this assay may prove pivotal in the development of biologically guided RT.
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