期刊
PEPTIDES
卷 107, 期 -, 页码 17-24出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2018.08.002
关键词
Cyanobacteria; Depsipeptide; Lipopeptide; Cyclamide; Antibiotic activity; Structure-activity relationship
资金
- National Natural Science Foundation of China (NSFC) [31672530, U1704117]
- Doctoral Foundation of Henan University of Science and Technology [4022/13480021]
Members of cyanobacteria, including Moorea spp., Okeania spp., Lyngbya spp., Schizothrix spp., Leptolyngbya spp., Microcystis spp., Symploca spp., Hassallia sp., Anabaena spp., Planktothrix sp., Tychonema spp., Oscillatoria spp., Tolypothrix sp., Nostoc sp., and Hapalosiphon sp. produce an enormously diverse range of peptide antibiotics with huge potential as pharmaceutical drugs and biocontrol agents following screening of structural analogues and analysis of structure-activity relationships (SAR). The need for novel antibiotic lead compounds is urgent, and this review summarizes 78 cyanobacteria-derived compounds reported since 2000, including 32 depsipeptides, 18 cyclic lipopeptides, 13 linear lipopeptides, 14 cyclamides, and one typical cyclic peptide. The current and potential therapeutic applications of these peptides are discussed, including for SAR, antituberculotic, antifungal, antibacterial, antiviral, and antiparasitic (anti-plasmodial, antitrypanosomal and antileishmanial) activities.
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