期刊
PEPTIDES
卷 58, 期 -, 页码 14-19出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2014.05.011
关键词
CGRP; Adipose; Lipolysis; Lipid; cAMP
资金
- Foundation for Research Science and Technology(FRST, NZ) [PMIX0210]
- Health Research Council of New Zealand [HRC03/190]
- Protemix Corporation
The neuropeptide, alpha-calcitonin gene-related peptide (alpha-CGRP), is expressed from sensory nerves that innervate fat. However, how alpha-CGRP may act in adipose tissue is unclear. Using 3T3-L1 adipocytes we observed that rat alpha-CGRP (r alpha-CGRP) evoked either a biphasic or monophasic reduction in intracellular free fatty acid (FFA) content. CAMP production was always monophasic and occurred when FFA responses were absent. Taken together with the observed potencies, these findings suggest that adipose tissue is a physiological target for alpha-CGRP. However, uncoupling of the FFA and CGRP-signaling responses with increasing passage number limits 3T3-L1 adipocytes as a suitable cellular model. (C) 2014 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据