期刊
PEPTIDES
卷 53, 期 -, 页码 148-158出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2013.04.009
关键词
Neuropeptide; In situ hybridization; Kinin analogs; Hindgut
资金
- NSERC Discovery
- USDA/DOD DWFP [0500-32000-00101R]
The dramatic feeding-related activities of the Chagas' disease vector, Rhodnius prolixus are under the neurohormonal regulation of serotonin and various neuropeptides. One such family of neuropeptides, the insect kinins, possess diuretic, digestive and myotropic activities in many insects. In this study, we have cloned and examined the spatial expression of the R. prolixus kinin (Rhopr-kinin) transcript. In addition, in situ hybridization has been used to map the distribution of neurons expressing the kinin transcript. Physiological bioassays demonstrate the myostimulatory effects of selected Rhopr-kinin peptides and also illustrate the augmented responses of hindgut contractions to co-application of Rhopr-kinin and a R. pro lixus diuretic hormone. Two synthetic kinin analogs have also been examined on the hindgut. These reveal interesting properties including a relatively irreversible effect on hindgut contractions and activity at very low concentrations. (c) 2013 Elsevier Inc. All rights reserved.
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