期刊
PEPTIDES
卷 42, 期 -, 页码 63-69出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2012.11.018
关键词
Peptidomics; Endogenous peptide; Tear; MALDI-TOF-TOF; Proline-rich protein 4; Polymeric immunoglobulin receptor
资金
- SBO grant of the Flemish Institute [IWT-50164]
Tear fluid is a complex mixture of biological compounds, including carbohydrates, lipids, electrolytes, proteins, and peptides. Despite the physiological importance of tear fluid, little is known about the identity of its endogenous peptides. In this study, we analyzed and identified naturally occurring peptide molecules in human reflex tear fluid by means of LC-MALDI-TOF-TOF. Tandem MS analyses revealed 30 peptides, most of which have not been identified before. Twenty-six peptides are derived from the proline-rich protein 4 and 4 peptides are derived from the polymeric immunoglobulin receptor. Based on their structural characteristics, we suggest that the identified tear fluid peptides contribute to the protective environment of the ocular surface. (c) 2012 Elsevier Inc. All rights reserved.
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