期刊
PEPTIDES
卷 39, 期 -, 页码 1-5出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2012.09.001
关键词
Antimicrobial peptide; Achatina fulica; Mytimacin; Mollusks
资金
- Chinese National Natural Science Foundation [31070701, 31000962, 31025025, 30971179, 31170814, 30972848, 31028006]
- Fundamental Research Funds for the Central Universities [2010ZD028]
Antimicrobial peptides (AMPs) are important components of the innate immunity. Many antimicrobial peptides have been found from marine mollusks. Little information about AMPs of mollusks living on land is available. A novel cysteine-rich antimicrobial peptide (mytimacin-AF) belonging to the peptide family of mytimacins was purified and characterized from the mucus of the snail of Achatina fulica. Its cDNA was also cloned from the cDNA library. Mytimacin-AF is composed of 80 amino acid residues including 10 cysteines. Mytimacin-AF showed potent antimicrobial activity against Gram-negative and Gram-positive bacteria and the fungus Candida albicans. Among tested microorganisms, it exerted strongest antimicrobial activity against Staphylococcus aureus with a minimal peptide concentration (MIC) of 1.9 mu g/ml. Mytimacin-AF had little hemolytic activity against human blood red cells. The current work confirmed the presence of mytimacin-like antimicrobial peptide in land-living mollusks. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
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